Over the next 6 years word of his bitters and their medicinal practicallities had spread and with Angostura being an important trading post on the Orinoco River, the bitters were being shipped around the world. By the time of his death in 1870, he had formed a partnership with his son Carlos, who travelled the world to exhibt the bitters and their practical uses. By the turn of the 20th century, having decided that Venezuela was not as politically stable as would be desired, the Angostura company moved to the Caribbean island of Trinidad, where it has been ever since.